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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG2 All Species: 23.64
Human Site: S785 Identified Species: 47.27
UniProt: P16885 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16885 NP_002652.2 1265 147870 S785 Y D Y K A K R S D E L S F C R
Chimpanzee Pan troglodytes XP_001147944 1265 147906 S785 Y D Y K A K R S D E L S F C R
Rhesus Macaque Macaca mulatta XP_001111677 1265 147898 S785 Y D Y K A K R S D E L S F C R
Dog Lupus familis XP_546812 1252 146274 S785 Y D Y K A K R S D E L S F C R
Cat Felis silvestris
Mouse Mus musculus Q8CIH5 1265 147573 S785 Y D Y K A K R S D E L T F C R
Rat Rattus norvegicus P24135 1265 147716 S785 Y D Y K A K R S D E L T F C R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508105 991 115582 N524 C R G A L I H N V L K E A G G
Chicken Gallus gallus Q2VRL0 637 72514 S170 L C D Y F I S S S H N T Y L V
Frog Xenopus laevis Q32NH8 758 87399 D291 A H E Q L Y Q D M M Q P L C H
Zebra Danio Brachydanio rerio A5D6R3 784 89362 K317 H V Y Q D M S K P L A H Y Y I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624101 1134 132613 R667 E L V N Y Y E R H P L Y K K I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 D473 D H G W W K G D Y G G K K N M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98 94.4 N.A. 94.1 94.7 N.A. 62.7 20.7 22.1 21.2 N.A. N.A. 40.9 N.A. 32.9
Protein Similarity: 100 99.9 99.2 97 N.A. 97.1 97.3 N.A. 67.8 33.2 37.5 34.9 N.A. N.A. 59.1 N.A. 49
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 0 6.6 6.6 6.6 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 6.6 20 20 26.6 N.A. N.A. 6.6 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 9 50 0 0 0 0 0 9 0 9 0 0 % A
% Cys: 9 9 0 0 0 0 0 0 0 0 0 0 0 59 0 % C
% Asp: 9 50 9 0 9 0 0 17 50 0 0 0 0 0 0 % D
% Glu: 9 0 9 0 0 0 9 0 0 50 0 9 0 0 0 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 0 50 0 0 % F
% Gly: 0 0 17 0 0 0 9 0 0 9 9 0 0 9 9 % G
% His: 9 17 0 0 0 0 9 0 9 9 0 9 0 0 9 % H
% Ile: 0 0 0 0 0 17 0 0 0 0 0 0 0 0 17 % I
% Lys: 0 0 0 50 0 59 0 9 0 0 9 9 17 9 0 % K
% Leu: 9 9 0 0 17 0 0 0 0 17 59 0 9 9 0 % L
% Met: 0 0 0 0 0 9 0 0 9 9 0 0 0 0 9 % M
% Asn: 0 0 0 9 0 0 0 9 0 0 9 0 0 9 0 % N
% Pro: 0 0 0 0 0 0 0 0 9 9 0 9 0 0 0 % P
% Gln: 0 0 0 17 0 0 9 0 0 0 9 0 0 0 0 % Q
% Arg: 0 9 0 0 0 0 50 9 0 0 0 0 0 0 50 % R
% Ser: 0 0 0 0 0 0 17 59 9 0 0 34 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 % T
% Val: 0 9 9 0 0 0 0 0 9 0 0 0 0 0 9 % V
% Trp: 0 0 0 9 9 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 50 0 59 9 9 17 0 0 9 0 0 9 17 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _